Nfl Week 2 Picks 2024 Straight Up Predictions. Buffalo bills @ miami dolphins (8:15 p.m., prime video) point spread: Check out the nfl week 2 spreads and money line favorites at all of the best online sportsbooks below.

Six underdogs won straight up in nfl week 2 in 2022. We make picks for all 16 nfl games with levels of confidence ahead of week 1.